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Although there is theoretical concern that collagen and gelatin (including gelatin capsules) derived from cows could be contaminated with the infectious agent that causes mad cow disease, these ingredients are not derived from high-risk tissue and are subject to regulations that make this unlikely

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However, in the pivotal Phase IIb trial, it failed to demonstrate statistically significant weight loss compared to placebo at the primary endpoint, leading the developer (Metabolic Pharmaceuticals Ltd.) to terminate the commercial program

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After incorporation into the gel system, it showed enhanced skin deposition, efficient occlusion properties, improvement in antioxidant properties, and inhibition of tyrosinase enzyme action in comparison to conventional curcumin-plain gel [89]