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Shmerling & Greisen, 2025)

In specific, electrophysiological studies conducted on transgenic APPSwe mice, a rodent model of Alzheimers disease (AD), revealed that GABA-induced currents in the dentate gyrus (DG) of the hippocampus are not altered in this area by age alone but in combination with the presence of Alzheimers disease pathology (Hammoud et al., 2021)

4a), and the following stainings were performed to characterise the organoid composition: synaptophysin, S-100 and glial fibrillary acidic protein (GFAP) in the isogenic brain organoids (Fig