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Association of active caspase 8 with the mitochondrial membrane during apoptosis: potential roles in cleaving BAP31 and caspase 3 and mediating mitochondrion-endoplasmic reticulum cross talk in etoposide-induced cell death

& Tononi, G

In an in vitro study of PQ-treated lung epithelial cells (MLE-12 cells), Quercetin was found to modulate the fibrotic process mediated by the TGF-1/Smad and Akt/mTOR signaling pathways, altering the expression of markers of the epithelial-mesenchymal transition (EMT) and inhibiting the onset of fibrosis, resulting in improved cell survival

Nat Rev Immunol 11(2):119130 Capon F (2017) The genetic basis of psoriasis

doi: 10.1016/j.biopsych.2003.10.010 265 TurcuASmithJMAuchusRRaineyWE

238,239 Senescent macrophages in the eyes secrete proinflammatory cytokines via STAT3 signaling, aggravating retinal damage and promoting neovascularization, a hallmark of AMD