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Different studies supported that TGF-1 suppresses gene expression of glutamate cysteine ligases (GCL), an enzyme implicated in the biosynthesis of GSH, in alveolar epithelial cells (Jardine et al., 2002)

In contrast to the other fatsoluble vitamins, the German National Nutrition Survey II (20052007) did not provide any data concerning actual intake, intake below recommended values or supplementation

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Once the hepatotoxicity due to APAP was recognized, the mechanisms behind this were extensively investigated, especially in the mouse model, which recapitulates key mechanistic aspects of liver injury in humans such as mitochondrial dysfunction [5,6]