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It can interfere with thiamine absorption and increase thiamine excretion in the urine, leading to thiamine deficiency

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SAT1, Spermidine/spermine N1-acetyltransferase

Symptoms of vitamin B12 deficiency include: fatigue, irritability, anxiety, low energy, depression, forgetfulness, constipation, new food sensitivities, hot and cold flashes, sore muscles, pale skin, numbness, tingling, and dermatitis

Correcting deficiency can meaningfully support bone health and normal immune function

GCL forms an unusual peptide bond between the -carboxyl of glutamate and the amino group of cysteine using the energy provided by the hydrolysis of ATP (Lu, 2013)