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Age-related changes in expression of transforming growth factor-beta and receptors in cells of intervertebral discs

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Although the protection against necrosis was still present at 24 h, there was clear evidence of a limited number of apoptotic cells and caspase activation [58]

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Furthermore, the binding of plasma-derived molecules to the glycocalyx can result in a local concentration gradient, which is a common feature of the transcriptional and developmental processes that are regulated by growth factors (30, 31)