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Harmanjeet H, Zaidi STR, Ming LC et al

doi:10.1093/ehjcvp/pvae074

This metabolic imbalance, coupled with hyperinsulinemias effect on ovarian steroid hormone production by blocking LH, contributes to the cessation of follicular development, infertility, and anovulation ( Given its roles in metabolic and inflammatory regulation, the ECS has been proposed as a potential pharmacologic target in PCOS

These results suggest that NNT loss-of-function leads to reductive stress through increasing NADH accumulation and decreasing NADPH production, and that NNT can integrate with the PDH complex to form a redox circuit regulating H 2 O 2 production

This suggests that higher ROS levels in mutant-RAS driven cancers enhance dependency on GSH production for survival and that SLC7A11 associated ferroptosis suppression may support mutant-KRAS driven cancer growth

demonstrated that improving mitochondrial metabolism, reducing oxidative stress and mitochondrial fission via the deletion of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), thus alleviating sepsis-mediated myocardial injury, liver injury, and kidney injury in a sepsis model