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Oxidative stress refers to an imbalance between the production of reactive oxygen species (ROS) and the capability of the cell to detoxify these reactive intermediates or repair the resulting damage

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The disordered C-terminal domain contains MEIS1 activation domain (Bisaillon et al, 2011

These discrepancies likely reflect a non-linear relationship in which moderate mitochondrial dysfunction promotes migratory traits, whereas profound OXPHOS impairment constrains metastatic capacity in a tumor-type- and stage-dependent manner

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