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The key milestones include: exenatide approval (2005), liraglutide approval (2010), semaglutide injection approval (2017), oral semaglutide with SNAC approval (2019), orforglipron cryo-EM structure published (2020), orforglipron Phase 2 results in NEJM (2023), orforglipron Phase 3 ATTAIN-1 results in NEJM (2025), and FDA regulatory submission (2025)

its usually administered intramuscularly or subcutaneously in doses like 1,000 mcg for deficiency, on its own

B6 is vital for immune functions and serves as a biomarker of inflammation, with its down-regulation associated with severe inflammation

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Its long-acting nature means it can be dosed less often, which can be convenient for some users

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