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References Lee SJ, McPherron AC

According to the National Health Center of PTSD in the US, it is estimated that 3.5% of the US population (more than 11 million Americans) suffers from PTSD in a given year, but less than half of these patients are in proper treatment, and less than half of those in treatment receive minimally adequate care (Wang et al., 2005)

Miller AL

2.3 Neuroinflammation Some studies have shown that berberine activates macrophages and increases their phagocytic function, increases the production of interleukin (IL)-1, and enhances non-specific immunity, can be used as a neuroprotective agent to prevent Alzheimers disease (Kumazawa et al., 1984

And they are typically used together

Oxidative stress is a major hallmark of skin aging that may lead to DNA damage, mitochondrial dysfunction, and inflammation at the cellular levelall of which contribute to aging skin