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Statistical significance ( P values) of pairwise comparisons were calculated using unpaired, two-tailed Students t tests in Microsoft Excel (Version 16.80 for Mac) or GraphPad Prism 9.0

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Then researchers proposed that heterozygous knockout mice appeared to be a good animal model for individuals homozygous for the C667T polymorphism, whereas the homozygous null mice were a better one for severely MTHFR-deficient individuals 19

Diabetic cardiomyopathy (DCM) Evidence has shown that ferroptosis is crucial for DCM pathogenesis [48]

Further, we highlight the therapeutic potential of ferroptosis inducers and inhibitors, including small molecular agents and natural active ingredients, for delaying the progression of liver diseases in preclinical models

doi: 10.3390/metabo9030050 122 FujiiJHommaTKobayashiS