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Benefits: Improves circadian rhythm by promoting the delta rhythm, achieved in Stage 4 of sleep (the stage when Growth Hormone is made) Antioxidant effect in the brain via increases in glutathione peroxidase and superoxide dismutase Increased alertness, improved stress tolerance, and coping behavior during awake cycles Restoration of slow-wave sleep in Cushings Syndrome Possible anticonvulsant action by increasing the threshold to NMDA- and picrotoxin-induced convulsions Increase in testosterone levels when treating with DSIP alone (100-200 point increases have been observed) Side Effects: Potential to disrupt sleep

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Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer

Steroids are synthetic versions of hormones such as testosterone

Esophageal dysphagia and the K22 codes Esophageal dysphagia sits in a different chapter than the oropharyngeal type

Activated macrophage induced the expression of IFN- and TNF- cytokines, improving NADPH oxidase activity resulting in ROS production, such as oxygen-free radicals (O 2 ) superoxide