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In this population, butyrate enemas were also shown to significantly reduce NF-kB activity in lamina propria macrophages, which was associated with decreased inflammatory activity and lower disease activity index scores [52]

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single dose) upregulates GSH by activating the PKC-/Nrf2/GSS pathway, and significantly reduces cerebral infarction volume, neurological dysfunction, and neuronal ferroptosis induced by cerebral ischemia/reperfusion injury in male Sprague-Dawley rats [6]

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Further, ER stress was diminished by knockdown of each of the three genes (Figure 6E)