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Mitochondrial dysfunction and oxidative stress: a vicious cycle In ME/CFS, elevated ROS and RNS levels are associated with mitochondrial dysfunction by damaging mtDNA and membranes, disrupting the ETC, and triggering mitophagy

Ingredients like milk thistle help protect the liver and can support the bodys natural ability to produce its own glutathione

doi: 10.3389/fonc.2025.1700439 Received 11 September 2025 Accepted 27 October 2025 Published 17 November 2025 Volume 15 - 2025 Edited by Zodwa Dlamini, Pan African Cancer Research Institute (PACRI), South Africa Reviewed by Yuan Qin, Xijing Hospital, The Air Force Medical University, China Hong Sun, Fudan University, China Updates Copyright 2025 Ao, Liu, Yin and Zhao

, Higher Mediterranean Diet Quality Scores and Lower Body Mass Index Are Associated with a Less-Oxidized Plasma Glutathione and Cysteine Redox Status in Adults, J

In accordance with the elevated hepatic GSSG/GSH ratio in HFD-fed mice, HFD consumption markedly increased hepatic 4-hydroxynonenal formation (Fig

In its early stages, endometriosis can limit fertility through inflammatory signaling, which impairs both ovarian and fallopian tube function and can reduce normal follicle formation, fertilization, and implantation