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Each PCR reaction was composed of TopTaq DNA polymerase (Qiagen), 3% DMSO and 200 ng of extracted DNA

To obtain a global cognition Z-score, participants were annually assessed on 19 tests evaluating five cognitive domains: episodic memory, semantic memory, working memory, perceptual orientation, and perceptual speed

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Bipolar and schizophrenia risk gene AKAP11 encodes an autophagy receptor coupling the regulation of PKA kinase network homeostasis to synaptic transmission

It is administered via subcutaneous injection, though oral formulations are also being studied