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Dysregulation of apoptosis is associated with uncontrolled cell proliferation and accumulation of mutated cells, eventually developing and progressing the cancer and also the resistance to cancer therapy ( FIGURE 1 The apoptotic mechanism occurs in two main pathways: intrinsic and extrinsic (Wong, 2011)

In general, plants own very competent enzymatic [catalase (CAT), monodehydroascorbate reductase (MDHAR), superoxide dismutase (SOD), ascorbate peroxidase (APX), glutathione reductase (GR), dehydroascorbate reductase (DHAR), guaiacol peroxidase (GPX)] and non-enzymatic [glutathione (GSH), ascorbic acid (AsA), carotenoids, alkaloids, phenolic compounds as well as non-proteinaceous amino acids] antioxidative defensive systems which act in collaboration to regulate the problems of unrestrained oxidation and ultimately shield the plant cells from oxidants injury by scavenging these toxic ROS [11]

It is clinically used to treat hyperuricemia and is sometimes added to organ preservation solutions

When choosing BPA-free bottled water, consider both the water and the container

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Hartlmller, C., Spreitzer, E., Gbl, C., Falsone, F