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It is administered either intravenously or by surgical implantation of a BCNU wafer

Pillai, S

Deshayes S, Plnat T, Aldrian-Herrada G, Divita G, Le Grimellec C, Heitz F

Mice were housed at the University of North Texas Health Science Center and are hereafter referred to as MitoQC mice

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53

A2ARi treatment caused enhanced expression of gls , gls2 , gclm , gclc , and slc7a11 (which encode the key enzymes and transporter for glutamine-derived GSH biosynthesis) as well as slc25a39 (which encodes the only mitochondrial membrane transporter for mitochondrial GSH import), driving the de novo GSH biosynthesis and the mitochondrial GSH-import machinery, respectively (Supplemental Figure 6C)