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Inconsistent dosing, varying between under and over, disrupts the steady-state concentrations many peptides require

FIGURE 1 Increasing evidence suggests that microbiota, specifically gut microbiota contributes to the drug metabolism (Li and Jia, 2013)

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Thus, interference with a single glutamine metabolic pathway or one part of that may have minimal effects in treating AML

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However, insulin and growth factor signaling can also induce lipid synthesis via mTORC1-stimulated activation of SREBP and its lipogenic gene targets (Duvel et al., 2010