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As expected, auranofin treatment resulted in a significant reduction in PKC/ activity compared to vehicle-treated controls, evidenced by a decrease in phospho-PKC/ levels at the activation loop (Thr403, Fig

Work in human biopsy models has shown that IL-12p35 was not expressed within psoriatic skin lesions, whereas p40 in IL-12 and IL-23, along with IL-23p19, were significantly expressed

Transcripts encoding for Cdkn1a and SASP components, such as Ccl2 and Ccl5 , were upregulated in cisplatin-treated mice and significantly reduced in mice undergoing combination treatment (Extended Data Fig

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These findings suggest that while turmeric itself does not contain glutathione, its active component curcumin can positively impact glutathione levels and activity in the body

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