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Statements Author contributions AL: Writing original draft

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The blood sugar effect of peptides is typically not a concern for non-diabetics, but in this case, the individual experienced severe gastrointestinal effects, highlighting the importance of caution when using these drugs 1m6s

To overcome these limitations, the researchers designed and synthesized novel small molecules with improved metabolic stability, BBB penetrability, and oral activity

In absence of modification on the downstream signaling pathway, G protein uncoupling is a good marker for desensitization but can't be applied for G protein-independent pathways (i.e., MAP kinases)

As a key component in detoxification pathways, GSH can facilitate the safe excretion of metabolic wastes and heavy metals