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These K ATP channel openers induced analgesic effects by activating specific signaling pathways, such as the growth arrest-specific 6 (Gas6)/Axl/suppressor of cytokine signaling 3 (SOCS3) pathway in microglia, which helps attenuate neuroinflammation and postoperative pain (Zhu et al., 2015

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doi: 10.3233/JAD-2011-101965 88 PisaD.AlonsoR.JuarranzA.RbanoA.CarrascoL

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