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Accordingly, novel strategies aimed either at preventing mGSH depletion, such as mitochondrial cholesterol lowering agents for liver pathologies, or drugs capable of increasing mGSH levels need to be pursued from a therapeutic perspective

Specifically, 2-Oxatricyclo [4.3.1.0(3,8)] decane and pulegone demonstrate blood-brain barrier (BBB) penetration

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10.1016/j.celrep.2016.11.001 39 GaoR.PengX.PerryC.SunH.NtokouA.RyuC.et al (2021)

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For instance, OPA1 knockdown-induced reduction in fusion also facilitates the elimination of dysfunctional mitochondria [39]