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Effect of Bupleuronin A on p-glycoprotein expression in multidrug resistant epileptic rats

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Studies suggest that various molecular pathways are involved in IC/BPS, including the JUN N-terminal kinase (JNK) pathway, transient receptor potential (TRP) channels, activated mast cells, mucosal signalling, circadian rhythm regulation, inflammation and neural dysregulation

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Studies in 1976 further demonstrated that although intracellular Met levels in cancer cells are normal or even elevated, their proliferation remains absolutely dependent on exogenous Met, a contradictory occurrence known as the Hoffman effect (35)

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