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When AGEs bind to receptors known as RAGEs, they activate inflammatory signaling pathways like NF-B and mitogen-activated protein kinase (MAPK) and encourage the expression of fibrotic markers like TGF-1 and fibronectin (FN) in GMCs

Phytomedicine Int

However, contrasting findings of normal or even slightly higher intracellular GSH in certain CF cell lines exist (Bergamini et al., 2009)

Beyer RE

Regulation of cell surface proteins Thiols such as GSH are also present in the extracellular space, where they play an important role in cell surface protein regulation and signal transduction

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