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The selective elimination of senescent cells or support for the body in this process through the modulation of autophagy in them, coupled with limiting the impact of senescent cells on their environment, may prove highly effective in anti-cancer therapy [9]

The pathogenesis of melanoma induced by ultraviolet radiation

For further prognostic evaluation and clinical decision-making, breast cancer can be classified into three subgroups based on immunohistochemical staining results for ER, PR, and HER2: HR-positive/HER2negative (HR+/HER2, ~70%), HER2positive (HER2+, ~1520%), and triple-negative breast cancer [TNBC, HR-negative (HR-), HER2, ~15%]

Even more intriguing are the systemic effects observed with topical application

J Biol Chem 1971;246(1):6973