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Administration Routes in Research Syn-AKE has been investigated exclusively through topical application routes: Topical cream formulations Most common delivery method in human studies

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[] The clinical relevance of PPARs in human cardiometabolic diseases is well established

However, in some other tissues, IGF-I expression appears to be regulated by tissue specific trophic factors, as for example in uterus, where estrogens (and not GH) stimulate IGF-I expression[26], while follicle stimulating hormone is a major IGF-I regulator in ovary[27]

Women between 40 and 60 years old face the highest risk