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When its levels increase, it facilitates improved fat metabolism and energy expenditure

This gap in basic research makes it difficult to accurately predict and optimize combination drug regimens, potentially compromising efficacy or elevating risks

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Wojtuszkiewicz A, Barcelos A, Dubbelman B, De Abreu R, Brouwer C, Bkkerink JP, de Haas V, de Groot-Kruseman H, Jansen G, Kaspers GL, Cloos J, Peters GJ (2014) Assessment of mercaptopurine (6MP) metabolites and 6MP metabolic key-enzymes in childhood acute lymphoblastic leukemia