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4428-A PFOA EXPOSURE RESULTS IN SEX-DEPENDENT EFFECTS ON HEPATIC AND WHOLE-BODY LIPID HOMEOSTASIS THAT DIFFER BY PPARA STATUS Frederick Ekuban 1 , Greylin Nielsen 2 , Dibson Dibe Gondim 1 , Wendy Heiger-Bernays 2 , Thomas Webster 2 , Matthew Cave 1,3 and Jennifer Schlezinger 2 , (1)University of Louisville, Louisville, KY, (2)Boston University, (3)Robley Rex VAMC Background: Per- and polyfluoroalkyl substances (PFAS) are a large group of persistent chemicals that have been released pervasively in the environment leading to widespread exposure for human populations

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Elevated metallothionein expression in long-lived species mediates the influence of cadmium accumulation on aging

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However, research on ferroptosis mechanisms in CHD remains in its nascent stages, with numerous crucial questions awaiting resolution