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In addition to acting directly on cancer cells, L-theanine also has beneficial effects in radiotherapy and chemotherapy

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The overproduction of 5-oxoproline exceeds the capacity of its degradative enzyme, 5-oxoprolinase, and 5-oxoproline therefore accumulates in body fluids and is excreted in the urine

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In a chronic model, mice were treated with Icariin 25 mg per kg administered intraperitoneally to 10 days before the initial dose of CYP that is 75 mg per kg given through an intraperitoneal route every 3 days for about 10 days to decrease the edema and hemorrhage of bladder, vascular permeability, and mast cells infiltration as well as fibrosis of the lesion tissue

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