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In long-term follow-up, the concomitant use of corticosteroids significantly increases the risk of infections [346], and very rare cases of multiple immune modulation-related malignancies have also been reported [341]

One speculation is that although adipocytes have reduced GPX4, adipocytes may be similar to some tumor cells, which still have a high level of GSH in their cells, so that although adipocytes are in an overall oxidative stress condition, the remaining GPX4 from GSH is still needed to neutralize large amounts of ROS and remove some of the lipid peroxides, resulting in differentiated adipocytes that are not or less affected by ferroptosis (81)