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Therefore, Nrf2 establishes distinct routes for controlling other elements of NLRP3 inflammasome-mediated damage to cells, including mitochondria, by interacting with several mediators [88]

1) Impaired histamine breakdown: There are two ways your body breaks down and clears histamine: the DAO enzyme or the HMNT enzyme.[ref] Diamine oxidase (DAO) enzyme: breaking down and inactivating histamine in the gut Diamine oxidase is encoded by the AOC1 gene

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Frame J, Slinger P, Butler B, Good B, Marancik D (2019)