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Elevated hepatocyte apoptosis is well documented as a distinct feature of MASH [222]

Neurology 88(22):21152122 Southwood C, He C, Garbern J, Kamholz J, Arroyo E, Gow A (2004) CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure

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Abbreviations PD: Parkinsons disease NAC: N-acetylcysteine GSH: Glutathione GSSG: Glutathione disulfide UPDRS: Unified Parkinsons Disease Rating Scale CSF: Cerebrospinal fluid DAT: Dopamine transporter MRS: Magnetic resonance spectroscopy MPP: 1-methyl-4-phenylpyridinium MPTP: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ADL: Activities of daily living MoCA: Montreal cognitive assessment 4-HNE: 4-hydroxynonenal 6-OHDA: 6-hydroxydopamine L-DOPA: Levodopa ECG: Electrocardiogram SPECT: Single-photon emission computed tomography PROMIS: Patient-reported outcomes measurement information system PDQ-39: Parkinsons Disease Questionnaire-39 PRO-PD: Patient-reported outcomes in Parkinsons disease H&Y: Hoehn and Yahr MMSE: Mini-mental state examination CBC: Complete blood count ALT: Alanine aminotransferase AST: Aspartate aminotransferase BUN: Blood urea nitrogen SOD: Superoxide dismutase MCID: Minimal clinically important difference SD: Standard deviation References Ball N, Teo W-P, Chandra S, Chapman J (2019) Parkinsons disease and the environment

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doi: 10.1038/s41420-021-00709-4 29 YeLFChaudharyKRZandkarimiFHarkenADKinslowCJUpadhyayulaPSet al