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Researchers developed a synthetic version of IGF-1 called IGF-1 LR3 (long arginine 3-IGF-1) so they could study the actions of this hormone for longer periods

Skolnik EY, Batzer A, Li N, Lee CH, Lowenstein E, Mohammadi M, Margolis B, Schlessinger J: The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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For perimenopause specifically, hormonal fluctuation drives many of the most disruptive symptoms estrogen can spike and crash erratically, which is why some patients feel worse in early perimenopause than in full menopause