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In yet another aspect, there is provided a method of sensitizing cancer cells in a subject to cytotoxic CD8+ T cell-mediated killing and/or immune checkpoint therapy, the method comprising administering to the subject a therapeutically effective amount of a) at least one agent that down-regulates the copy number, amount, and/or activity of at least one target listed in table 1 in or on monocytes and/or macrophages

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