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This modification was confirmed through immunoblotting and isotope labeling experiments, demonstrating that it originates from intracellular glycolysis [3]

24 Notably, the cytoplasm contains minimal free zinc since intracellular zinc is mainly sequestered in organelles like the ER, Golgi apparatus, and mitochondria, the so-called zinc store

They secrete growth factors (e.g., TGF-, VEGF, glia cell-derived neurotrophic factor) and exosomes containing beneficial miRNAs (such as miR-10a and miR-369-3p) that support the survival and proliferation of GCs and inhibit apoptosis (Xiao et al

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Supporting this, lipid peroxidation, a key marker of ferroptosis, was significantly increased following FADS knockdown (Fig