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Mitochondrial CYP27B1 is the only enzyme (requires Mg ++ ) that hydroxylates carbon number one in cholecalciferol, activating 25(OH)D3 (Bikle, 2014

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Increased serum cortisol levels in patients with schizophrenia and MDD Our study replicated previous findings that cortisol levels are significantly higher in patients with MDD and schizophrenia than in controls 3,4,6,7