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Together, these vitamins work synergistically to protect against oxidative damage and support cellular health [192]

doi: 10.1016/j.yhbeh.2021.104994 55 MarascoV.StierA.BonerW.GriffithsK.HeidingerB.MonaghanP

In HUVECs subjected to normal (1 mM) and low (0.1 mM) Mg 2+ concentrations for 24 h, in a custom-made Mg 2+ -free medium supplemented with magnesium sulfate (MgSO 4 ), Mg 2+ deficiency upregulated the pro-oxidant protein thioredoxin-interacting protein (TXNIP), a contributor to ROS generation, increased endothelial permeability (altering inter-endothelial junctions by disrupting VE-cadherin distribution), and promoted the accumulation of triglycerides in lipid droplets [202]

Li Vivian SW, Ng Ser S, Boersema Paul J, Low Teck Y, Karthaus Wouter R, Gerlach Jan P, Mohammed S, Heck Albert JR, Maurice Madelon M, Mahmoudi T, Clevers H (2012) Wnt signaling through inhibition of -catenin degradation in an intact axin1 complex

And this is also evident at the IGF-I function level

Li G, Xu Y, Wang S, Yan W, Zhao Q, Guo J