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doi:10.1016/j.expneurol.2009.04.004 Vanhoutte N, Hermans E (2008) Glutamate-induced glioma cell proliferation is prevented by functional expression of the glutamate transporter GLT-1

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Furthermore, research indicates that quercetin exerts its anti-inflammatory effects by inhibiting the expression of cytokines and nitric oxide synthase, which is mediated by the suppression of the NF-B pathway, while not affecting the activity of terminal-c-Jun N kinase

This epigenetic reprogramming induces immunosuppressive phenotypes in immune cells that are resident in the tumor microenvironment, including impaired effector function, enhanced immunosuppressive cytokine secretion, and altered tumor antigen presentation, collectively facilitating immune escape

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