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Animals Male Wistar rats sourced from the animal facility of the Medical Bioscience department, University of the Western Cape, had free access to standard rat chow and tap water ad libitum

doi: 10.1074/jbc.M004850200 39 RosenbergJBDeBPGrecoAGormanNKoonerVChenAet al

The specific mechanisms of neuronal demyelination of large neuronal fibers caused by vincristine and paclitaxel are unclear, however the disruption of microtubule function and the subsequent impairment of retrograde and anterograde axonal transport of essential cellular components may play a role (Sahenk et al., 1994

Brain pericytes contribute to the induction and up-regulation of bloodbrain barrier functions through transforming growth factor-beta production

Preterm-born individuals have been shown to have significantly lower forced expiratory volume in 1 s (FEV 1 ) than those born at term 11 , therefore providing a potential therapeutic window of opportunity for optimizing peak lung function, and highlights the importance of understanding the underlying mechanisms of PLD during childhood

Red Blood Cell Production B12 is essential for healthy red blood cell formation and helps prevent certain types of anemia