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Therefore, Mfn2 is proposed as a sensor and regulator of metabolic homeostasis in multiple tissues

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17:119140 Panagaki T, Randi EB, Augsburger F, Szabo C (2019) Overproduction of H 2 S, generated by CBS, inhibits mitochondrial complex IV and suppresses oxidative phosphorylation in Down syndrome

Cell 185 , 34413456.e3419 (2022)

In contrast, the downregulated DEGs were enriched in pathways related to protein processing, transport, and carbon fixation by Calvin cycle ( Figure 5C, D )