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Such platforms have demonstrated how proteasome inhibition induces a functional handover toward autophagy-dependent degradation, 9 reflecting intrinsic compensatory resilience

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Rapid detection of gut microbial metabolite trimethylamine N-oxide for chronic kidney disease prevention

In a model of amyotrophic lateral sclerosis (ALS) caused by C9orf72 gene mutations, the pathogenic poly-dipeptide GA50 directly binds to and inhibits SQOR, leading to excessive NLRP3 inflammasome activation in microglia and consequent mitochondrial dysfunction ( A growing body of preclinical work supports this strategy: boosting SQOR activity or reducing H 2 S can protect the nervous system

Anisotropic truncated octahedral au with pt deposition on arris for localized surface plasmon resonance-enhanced photothermal and photodynamic therapy of osteosarcoma