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In this trial, once-weekly cagrilintide-semaglutide for 68 weeks in adults with overweight or obesity was highly effective and led to substantial and clinically meaningful weight loss, the authors concluded

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Lysosomal degradation of TBK1 is also promoted by ubiquitin specific peptidase 19 (USP19), which interacts with the TBK1-HSPA8 complex via the chaperone-mediated autophagy (CMA) motif of TBK1 (190) ( Figure 6 )

Preliminary findings in both animal models and small human studies suggest a reduction in craving and intake, sparking considerable interest in larger clinical trials

doi: 10.1186/s12958-018-0359-5 18 AlvarezJHansenAGOrdTBbasPChappellPEGiebutowiczJMet al