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By inhibiting NF-B activation, curcumin effectively downregulates the expression of a vast array of pro-inflammatory genes, including those encoding cytokines such as interleukin-1 beta (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) [15, 16]

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The mechanisms highlighting the versatility of nanomaterials in addressing various aspects of neuronal damage, are explained in Table 1

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