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In the chronic kidney disease (CKD) state, declining renal function leads to substantial urea excretion into the intestinal tract, where it is hydrolyzed by microbial urease to ammonia, converting to ammonium hydroxide and elevating luminal pH (100)

These novel entities ingeniously fuse the selenocyanate moiety with a variety of heterocyclic rings, quinones, or steroidal frameworks, thereby expanding the horizons of selenium-based therapeutics

doi:10.1016/j.jep.2022.115066

612 However, there are currently no effective interventions for HD patients

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Oral supplements pass through the digestive tract to be absorbed by the bloodstream, and much of the nutrient is lost in this process