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In another recent study, Marotti et al

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coli ribosomes revealed the extensive formation of peptide persulfides, suggesting that protein supersulfidation occurs during protein synthesis ( Figure 2 )

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The apparent second-order rate constant for inactivation of the enzyme by acrolein (k inact /K I = 87 M -1 s -1 ) is comparable to that for hydrogen peroxide (10 M -1 s -1 ) [122], a known endogenous regulator of PTP1B activity