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this adjustment is termed metabolic reprogramming ( Furthermore, the influence of metabolic reprogramming extends beyond individual pathways, being affected by broader factors such as hypoxia and the TME ( 5 sEVs promote tumor metastasis in EOCs In the TME, sEVs play a pivotal role for transmitting information

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10.1016/j.cmet.2013.12.008 142 Lpez-OtnC.GalluzziL.FreijeJ

Moreover, anti-tumor research also emphasizes the significance of SIRTs (sirtuins), which belong to the family of NAD (+)-dependent class III histone deacetylases