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The enzyme is located on the cytosolic surface of the endoplasmic reticulum (Okajima et al., 1984)

A study showed that treating K14-HPV/E2 mice with Zoledronic acid (ZA), a bisphosphonate used for skeletal metastasis with anti-inflammatory and anti-osteoclast properties, resulted in the suppressed mobilization of VEGF-A and, consequently, the inhibition of angiogenesis and tumourigenesis [65]

Safety is where the injectable-versus-topical distinction stops being academic

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