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*Correspondence: Irene Mattiola, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Some compete with each other for absorption

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Creatinine levels above 1.2 mg/dL in women and 1.4 mg/dL in men indicate reduced filtration, while protein in urine (proteinuria) often appears before other symptoms