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J Crohns Colitis 2013

Oxidative stress and antioxidant defense mechanisms linked to exercise during cardiopulmonary and metabolic disorders

(88) in an 8-week randomized double-blind, placebo-controlled trial with 80 individuals experiencing episodic migraines, discovered that the combination of omega-3 PUFAs and nano-curcumin significantly reduced migraine attack frequency and serum levels of IL-1 in a synergistic manner, though the initial significant reduction in IL-1 gene expression did not remain significant after Bonferroni corrections

Cardiovascular symptoms occurred in about 55% of patients, with bradycardia and hypotension typically presenting as the initial sign

32 patient cohorts) and 1.9-fold higher odds of 3-month mortality (pooled OR 1.87

Of these findings, reduction in psychopathology ratings, though statistically significant, appeared too small to be clinically meaningful