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Bernards, High-throughput functional genetic and compound screens identify targets for Senescence induction in Cancer

The FDA can take it or leave it," Tatem noted

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doi: 10.3389/fphar.2021.632295

The selectivity of FOXO4-DRI for senescent over non-senescent cells is mechanistically grounded: FOXO4 is expressed at low levels in most non-senescent adult cells, but is strongly upregulated in senescent cells